Reduced Folate Carrier: an Entry Receptor for a Novel Feline Leukemia Virus Variant
نویسندگان
چکیده
منابع مشابه
In vivo evolution of a novel, syncytium-inducing and cytopathic feline leukemia virus variant.
Studies of feline leukemia virus (FeLV) have illustrated the importance of the genotype of the infecting virus in determining disease outcome. In FeLV infections, as in other retroviral infections, it is less clear how virus variants that evolve from the transmitted virus affect pathogenesis. We previously reported an analysis of the genotypic changes that occur in the viral envelope gene (env)...
متن کاملFeline leukemia virus and feline immunodeficiency virus.
Ophthalmic manifestations of FeLV or FIV infection can occur in all ocular tissues and may be manifestations of direct viral effects or secondary to viral-related malignant transformation. Additionally, the manifestations of common feline ophthalmic pathogens may be more severe and poorly responsive to therapy because of the immunosuppressive effects of FeLV or FIV infection. Prompt diagnosis o...
متن کاملFeline leukemia virus & feline immunodeficiency virus.
RISK OF INFECTION/EXPOSURE The risk of infection is higher in younger animals and cats that are in contact with multiple cats (strays). Generally, Feline Leukemia Virus (FeLV) is spread by casual contact between cats although as they age, resistance to infection develops. Feline Immunodeficiency Virus (FIV) is spread more commonly through bite wounds or through sexual behaviour. Exposure occurs...
متن کاملFeline Leukemia Virus
Feline leukemia virus (FeLV) is a retrovirus, a family of viruses which has many members that infect cats and cause disease and death in cats around the world. Another well-known feline retrovirus is the feline immunodeficiency virus (FIV). FeLV and FIV can be found together in the same cat. The prevalence of FeLV in single-cat households is about 3% and can be as high as 11% in stray or high r...
متن کاملRole of reduced folate carrier in intestinal folate uptake.
Studies from our laboratory and others have characterized different aspects of the intestinal folate uptake process and have shown that the reduced folate carrier (RFC) is expressed in the gut and plays a role in the uptake process. Little, however, is known about the actual contribution of the RFC system toward total folate uptake by the enterocytes. Addressing this issue in RFC knockout mice ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2019
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.00269-19